Usually, it's ladies first, but today I'll go gents first, if only because it allows me to save the best for the last spot IMHO. I could also apply a saying we have in Germany, "Alter vor Schönheit", which translates to "age before beauty".
Here we go:
Dennis Quaid (60)
Sixty is a big birthday for sure. It also means he has a big career behind him, and hopefully also some ahead of him. But I won't discuss his whole filmography now, nor will I say anything about his marriage to Meg Ryan in the 90's, or remind anyone how it ended... I won't even state which of his performances is the best. I will only say for which role I will always remember him most, and I may be alone here. This clip is the closest I could find in a rather short time to my favorite quote from the 1989 movie "Great Balls of Fire":
By the way, Dennis Quaid was 35 when he played that role, but Jerry Lee Lewis is actually "only" 21 throughout most of the movie, as that is the age he was when he married Myra. Not that this makes it okay...